The Beverage Which Blocks The Onset of Ulcerative Colitis, Researchers Find

Kyle J. Norton 
 

Green tea may have a therapeutic and positive effect of blocking the onset of ulcerative colitis, some scientists suggested.

Ulcerative colitis is a digestive condition characterized by inflammatory bowel disease (IBD) that induces chronic inflammation and ulcers (sores) in the digestive tract.

According to statistic, approximately, between 250,000 and 500,000 people are infected by ulcerative colitis in the United States. The risk of ulcerative colitis onset is between 2 to 7 per 100,000 persons.

Most common symptoms are abdominal pain and diarrhea. However, some patients may also experience symptoms of fatigue or tiredness, loss of appetite, dehydration feeling the urge to empty the bowels constantly,…. and weight loss.

If you have some of the symptoms of above, please check with your doctor to rule out the possibility of ulcerative colitis.

Researchers do not know the exact cause of Ulcerative Colitis. 

Neither they know why ulcerative colitis induces chronic inflammation and ulcers (sores) in the digestive tract. 

However, they do know that certain risk factors are associated to the development of the disease, including genetic mutation of a certain gene, environmental toxins, overreaction of the immune system,…. and long-term high levels of linoleic acid intake.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

As yin in nature, long-term injection of large amounts may obstruct the balance of yin-yang, induced “yin excessive syndrome” or “yang vacuity syndrome” including weaken immunity and painful case of GERD,… according to traditional Chinese medicine’s Yin-Yang theory.

Mild to moderate ulcerative colitis (UC) patients, 15 received 400 mg or 800 mg of total Polyphenon E daily, administered in split doses or and 4 in placebo in a double-blinded, placebo-controlled pilot study, researchers at the end of the experiential indicated that oral administration of the extracts  exerts a potential effect of reduced levels of inflammation through the improvement of the reading of the mean UC disease activity index score compared to the entry score.

After 56 days of therapy, Polyphenon E  treatment group exhibited strong improvement of over response rate of 66.7% (10 of 15) and remission rate of 53.3% (8/15) compared to 0% (0/4) in both response rate and remission rate in the placebo group.

Dr. Dryden GW, the lead author, after taking into account of other co-founder said,”Administration of Polyphenon E resulted in a therapeutic benefit for(ulcerative colitis (UC)) patients who were refractory to 5-aminosalicylic and/or azathioprine”.

Polyphenon E is a high-quality tea catechin extracted from natural tea leaves. 

Further analysis of green tea bioactive polyphenols, epigallocatechin gallate (EGCG) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in rats and to explore the roles of TLR4/MyD88/NF-κB signaling pathway, indicated that application of the extract significantly improves the intestinal mucosal injury in rats though inhibited production of inflammatory factors which were overexpression during the acute phase of injuring and damage to induced further damage to the tissue.

Moreover, green tea bioactive polyphenols, epigallocatechin gallate (EGCG) also reduced chronic inflammation and maintained the balance of the ratio of Th1/Th2 T-helper (Th) lymphocytes that prevent alterations in cellular immunity in patients with ulcerative colitis.

Imbalance of Th1/Th2 was found to associate to the occurrence and development of ulcerative colitis.

Additionally, injection of green tea EGCG also reduced the levels of TLR4 signaling in activated the intracellular signaling pathway NF-κB and inflammatory cytokine production to imitate inflammation.

Amazingly, researchers also found that injection of TLR4 antagonism not only shows a significantly reduced the protective effect of EGCG on intestinal mucosal injury colitis but also increased the expressions of inflammatory factors in the production of pro-inflammatory cytokines.

Moreover, in the examine the antioxidant activity of green tea catechins in model of colitis induced by 2.4.6 trinitrobenzene sulfonic acid (TNBS) using 35 young adult Sprague-Dawley rats which are divided into four groups: normal control (n=5), catechins (n=9), TNBS (n=9) and 2.4.6 trinitrobenzene sulfonic acid (TNBS) plus catechins (n=12), at the end of the experiment researchers at the Joint study, American University of Beirut, found that groups with TNBS and catechin express strong anti-inflammatory and anti-oxidant effects of amelioration of symptoms and expression of ulcerative colitis through stabilizing the mast cells production, induced by injection of TNBS in compared to TNBS treated group.

Dr. the lead authors in the joint study suggested that the study depicted a significant amelioration in the TNBS- and EGCG-treated rats compared to the non-treated animals in similar to histological data, as the mechanism of action occurred basically through the NF-kB pathway and possibly through a crosstalk with other pathways.

Taken together, green tea and its bioactive polyphenols may be considered as functional foods for the prevention and treatment of ulcerative colitis through the expression of antioxidant and anti-inflammatory activity.

Intake of green tea extract should be taken with extreme care as acute toxicity has been reported in some cases.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

Sources
(1) A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis by Dryden GW1, Lam A, Beatty K, Qazzaz HH, McClain CJ. (PubMed)
(2) Tea catechins induce crosstalk between signaling pathways and stabilize mast cells in ulcerative colitis by Gerges Geagea A1,2, Rizzo M2, Eid A1, Hajj Hussein I3, Zgheib Z1, Zeenny MN1, Jurjus R4, Uzzo ML5, Spatola GF5, Bonaventura G5, Leone A5, Massaad-Massade L6,7,8, Jurjus A1. (PubMed)
(3) EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats by TNBS,1 Liu Xuelei,2 Dong Wanwei,3 Liang Linlang,1 and Chen Keyan3(Hindawi)