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ncbi.nlm.nih.gov › pmc › articles › PMC3028942
Botulinum toxin: Bioweapon & magic drug – PMC
Botulinum neurotoxin poses a major bioweapon threat because of its extreme potency and lethality; its ease of production, transport, and misuse; and the need for prolonged intensive care among affected persons. A single gram of crystalline toxin, evenly dispersed and inhaled, can kill more than one million people.
ncbi.nlm.nih.gov › pmc › articles › PMC6429496
Biological Toxins as the Potential Tools for Bioterrorism
In this paper we focused on six most danger toxins: botulinum toxin, staphylococcal enterotoxins, Clostridium perfringens toxins, ricin, abrin and T-2 toxin. We hope that this paper will help in understanding the problem of availability and potential of biological toxins.
emedicine.medscape.com › article › 829613-overview
CBRNE – Biological Warfare Agents – Medscape
Anthrax and botulinum toxin initially were investigated for use as weapons, and sufficient quantities of botulinum toxin and anthrax cattle cakes were stockpiled by June 1944 to allow limited retaliation if the Germans first usedbiological agents.
karger.com › ene › article › 84 › 1 › 53 › 125498 › Botulinum-Toxin-in…
Botulinum Toxin in WW2 German and Allied Armies: Failures and Myths of …
These studies led to a succession of failures and myths about the weaponization of botulinum toxin. Nevertheless, major progress (purification, toxoid) arose from the military research, providing useful data for the first steps of the therapeutic use of botulinum toxin in the post-war years. Keywords:
link.springer.com › chapter › 10.1007 › 978-3-030-03053-7_1
Historical Aspects of Biological Weapons Development and Use – Springer
Biological warfare is the use of microorganisms, toxins derived from living organisms, or bioregulators to deliberately cause the death or illness of humans, plants, or animals. 1 Biological weapons are unique among the instruments of warfare because they are composed of, or derived from, living organisms.
ojp.gov › … › abstracts › botulinum-toxin-biological-weapon
Botulinum Toxin as a Biological Weapon – Office of Justice Programs
Botulinum Toxin as a Biological Weapon. The Working Group on Civilian Biodefense makes recommendations for measures to be taken by medical and public health workers if botulinum toxin is used as a biological weapon. As the most poisonous substance known, botulinum toxin poses a major threat. It can be easily produced, transported and used.
pubmed.ncbi.nlm.nih.gov › 32108007
Botulinum Toxin as a Biological Warfare Agent: Poisoning … – PubMed
Botulinum toxin is also considered as a relevant biological warfare agent with an expected high number of causalities when misused for bioterrorist or military purposes. The current paper surveys the actual knowledge about botulinum toxin pathogenesis, the manifestation of poisoning, and current trends in diagnostics and therapeutics.
pubmed.ncbi.nlm.nih.gov › 11209178
Botulinum toxin as a biological weapon: medical and public … – PubMed
An aerosolized or foodborne botulinum toxin weapon would cause acute symmetric, descending flaccid paralysis with prominent bulbar palsies such as diplopia, dysarthria, dysphonia, and dysphagia that would typically present 12 to 72 hours after exposure. Effective response to a deliberate release of …
pubmed.ncbi.nlm.nih.gov › 21149997
Botulinum toxin: bioweapon & magic drug – PubMed
As a military or terrorist weapon, botulinum toxin could be disseminated via aerosol or by contamination of water or food supplies, causing widespread casualties. A fascinating aspect of botulinum toxin research in recent years has been development of the most potent toxin into a molecule of significant therapeutic utility .
wwwnc.cdc.gov › eid › article › 5 › 4 › 99-0411_article
Potential Biological Weapons Threats – Centers for Disease Control and …
The agents included smallpox, plague, anthrax, botulinum toxin, equine encephalitis viruses, tularemia, Q fever, Marburg, melioidosis, and typhus ( 10, 11 ). Criteria such as infectivity and toxicity, environmental stability, ease of large-scale production, and disease severity were used in determining which agents had a high probability of use.
en.m.wikipedia.org › wiki › Anthrax_weaponization
Anthrax weaponization – Wikipedia
Anthrax weaponization is the development and deployment of the bacterium Bacillus anthracis or, more commonly, its spore (referred to as anthrax ), as a biological weapon. As a biological weapon, anthrax has been used in biowarfare and bioterrorism since 1914. [ 1] However, in 1975 the Biological Weapons Convention prohibited the “development …
news.npr.org › news › specials › response › anthrax › features › 2001 › oct › …
NPR: America Responds — The History of Bioterrorism
One of the symptoms of anthrax – also known as ‘woolsorter’s disease’ — is boils. Other historical instances of what is now called bioterrorism include: Sixth Century B.C. One of the earliest reported uses of bioterrorism. Assyrians poison enemy wells with rye ergot, a fungus that causes convulsions if ingested.
ncbi.nlm.nih.gov › pmc › articles › PMC5330008
Toxins as biological weapons for terror—characteristics, challenges and …
The aim of this work is to review the characteristics, diagnosis, and treatment of category A and B toxins, including Botulinum neurotoxin, staphylococcal enterotoxin B, Clostridium perfringens epsilon toxin, and ricin, in order to raise clinicians’ awareness.
journals.lww.com › ijmr › Fulltext › 2010 › 32050 › Botulinum_toxin…
Botulinum toxin: Bioweapon & magic drug : Indian Journal of Medical …
As a military or terrorist weapon, botulinum toxin could be disseminated via aerosol or by contamination of water or food supplies, causing widespread casualties. A fascinating aspect of botulinum toxin research in recent years has been development of the most potent toxin into a molecule of significant therapeutic utility.
africacheck.org › fact-checks › meta-programme-fact-checks › …
Four grams of botox could kill everyone on earth – Africa Check
It starts with a warning that botox is the “deadliest poison in the world”, and shows a small bottle labelled “Botulinum Toxin Type A” and “Botox”. Could 4 grams of botox really kill all the people on the planet?
sciencedirect.com › science › article › pii › B9780128120262000037
Toxins as biological warfare agents – ScienceDirect
Toxins, from a pharmacological and toxicological perspective, can be considered chemical weapons. Comparison of physicochemical and functional characteristics place toxins between chemical warfare agents and biological warfare agents. There are several differences between toxins and traditional chemical warfare agents.
cdc.gov › botulism › bioterrorism
Bioterrorism and Botulism: The Threat | Botulism | CDC
A bioterrorism attack that causes botulism is unlikely to happen in the United States. However, Some countries with biological weapons programs have made botulinum toxin. Some groups have tried unsuccessfully to use botulinum toxin to harm people. The good news is that no reported cases of botulism in the United States have been linked to …
medlink.com › articles › neurologic-disorders-related-to…
Neurologic disorders related to biological warfare agents and toxins …
Key points. • Anthrax has been used as a biowarfare and bioterrorism agent, and repeated (though unsuccessful) attempts have been made to use botulinum toxin as a bioterrorism agent. • The Biological Weapons Convention, entered into force in 1975, prohibits the development, production, acquisition, transfer, stockpiling, and use of …
wwwnc.cdc.gov › eid › article › 5 › 4 › pdfs › 99-0411.pdf
vol. 5 no. 4 – Centers for Disease Control and Prevention
The agents included smallpox, plague, anthrax, botulinum toxin, equine encephalitis viruses, tularemia, Q fever, Marburg, melioidosis, and typhus (10,11). Criteria such as infectivity and toxicity, environmental stability, ease of large-scale production, and disease severity were used in determining which agents had a high probability of use.
pubmed.ncbi.nlm.nih.gov › 9244334
Iraq’s biological weapons. The past as future? – PubMed
Abstract Between 1985 and April 1991, Iraq developed anthrax, botulinum toxin, and aflatoxin for biological warfare; 200 bombs and 25 ballistic missiles laden with biological agents were deployed by the time Operation Desert Storm occurred. Although cause for concern, if used during the Persian Gulf War, Iraq’s biological warfare arsenal probably would have been militarily ineffective for 3 …
who.int › health-topics › biological-weapons
Biological weapons – World Health Organization (WHO)
Biological agents like anthrax, botulinum toxin and plague can pose a difficult public health challenge causing large numbers of deaths in a short amount of time. Biological agents which are capable of secondary transmission can lead to epidemics. … animal health, water supply, food safety, poison control, civil protection, law enforcement …
ncbi.nlm.nih.gov › pmc › articles › PMC6950065
Biosecurity Threat Posed by Botulinum Toxin – PMC – National Center for …
The literature reports a number of attempts to produce and use BoNT as a bioweapon in the past decades. … Clostridium botulinum and the Most Poisonous Poison; pp. 553–601. [Google Scholar] 5. Carrillo-Marquez M. Botulism. … Destruction of botulinum toxins in food and water; pp. 323–341. [Google Scholar] 20. Patocka J., Kuca K., Jun D …
cdc.gov › anthrax › bioterrorism
Bioterrorism and Anthrax: The Threat | Anthrax | CDC
If there’s a bioterrorist attack, Bacillus anthracis, the bacteria that causes anthrax, might be used. Anthrax is dangerous. It can make people and animals sick and even cause death. Anthrax is a likely choice because: It occurs naturally, can be made in a lab, and lasts in its environment. It can be released quietly, without anyone knowing.
disarmament.unoda.org › biological-weapons › about › what-are…
What are Biological Weapons? – UNODA
Biological weapons disseminate disease-causing organisms or toxins to harm or kill humans, animals or plants. They generally consist of two parts – a weaponized agent and a delivery mechanism. … Historical biological weapons programmes have included efforts to produce: aflatoxin; anthrax; botulinum toxin; foot-and-mouth disease; glanders …
ncbi.nlm.nih.gov › pmc › articles › PMC1326439
The history of biological warfare – PMC – National Center for …
Man has used poisons for assassination purposes ever since the dawn of civilization, not only against individual enemies but also occasionally against armies (Table 1).However, the foundation of microbiology by Louis Pasteur and Robert Koch offered new prospects for those interested in biological weapons because it allowed agents to be chosen and designed on a rational basis.
sciencedirect.com › science › article › pii › B9780128120262000013
Biological warfare agents: History and modern-day relevance
Biological agents to cause destruction have been used since 6th century BC, wherein it was the poisoning of wells and water supplies that was most common. The very first deliberate act of spreading disease occurred in 1346 at the Siege of Caffa (Feodosia, Ukraine), when a Tartar army disposed its plague-ridden dead over the walls of the …
ncbi.nlm.nih.gov › pmc › articles › PMC7150198
Biological Warfare: Infectious Disease and Bioterrorism – PMC
Botulinum toxin. The most toxic substance known is botulinum toxin. It is made by the anaerobic bacterium, Clostridium botulinum, and is the cause of botulism, a severe form of food poisoning. It has been proposed as a biological warfare agent but has actually found its most frequent application in cosmetics, under the name Botox.
britannica.com › technology › biological-weapon
Biological weapon | Types, Effects & History | Britannica
biological weapon, any of a number of disease-producing agents—such as bacteria, viruses, rickettsiae, fungi, toxins, or other biological agents—that may be utilized as weapons against humans, animals, or plants.. The direct use of infectious agents and poisons against enemy personnel is an ancient practice in warfare.Indeed, in many conflicts, diseases have been responsible for more …
ncbi.nlm.nih.gov › books › NBK441942
Biological Weapon Toxicity – StatPearls – NCBI Bookshelf
Category A agents include Bacillus anthracis (anthrax), Clostridium botulinum toxin (botulism), Yersinia pestis (plague), Variola major (smallpox), Francisella tularensis (tularemia), and viruses that cause hemorrhagic fevers (eg, Ebola virus, Marburg virus, Lassa virus).Category B agents include Brucella species (Brucellosis), Chlamydia psittaci (Psittacosis), Coxiella burnetii (Q fever …
centerforhealthsecurity.org › … › files › 2023-11 › anthrax.pdf
Factsheet | Bacillus anthracis (Anthrax)
The intestinal tract, mouth, or throat (oropharyngeal anthrax) may be infected. 3. Though the reported incidence of gastrointestinal anthrax is low, about . 1% of cases, these infections likely are underreported because they most commonly occur in underserved areas with poor access to healthcare and diagnostic testing. • Injection-related anthrax
ncbi.nlm.nih.gov › books › NBK441942
Biological Weapon Toxicity – StatPearls – NCBI Bookshelf
B anthracis causes gastrointestinal and inhalational anthraxinfection when used as a bioweapon. … The poison control center, infection control practitioner, and … 2018] Botulinum Toxin. Clostridium botulinum …
centerforhealthsecurity.org › … › files › 2023-11 › anthrax.pdf
Factsheet | Bacillus anthracis (Anthrax)
The intestinal tract, mouth, or throat (oropharyngeal anthrax) may be infected. 3. Though the reported incidence of gastrointestinal anthrax is low, about . 1% of cases, these infections likely are underreported because they most commonly occur in underserved areas with poor access to healthcare and diagnostic testing. • Injection-related anthrax
Botox | Botulinum Toxin | Botox Injections | MedlinePlus
Botox injections can be used to temporarily reduce wrinkles but can also treat other health problems such as severe sweating or lazy-eye. Learn how.
vcahospitals.com › know-your-pet › botulism-in-dogs
Botulism in Dogs | VCA Animal Hospitals
Botulism is a rare condition that can cause paralysis in dogs. It is caused by ingesting the botulinum toxin, which is produced by the bacteria Clostridium botulinum that can grow on raw meat and dead animals. The toxin can cause muscle paralysis and lead to death. It is difficult to diagnose and there is no vaccine available, although an antitoxin is available if the condition is identified …
ncbi.nlm.nih.gov › pmc › articles › PMC7305902
Biowarfare, bioterrorism and biocrime: A historical overview on …
Confederates troops contaminate water supplies for the Union forces with animal corpses End of … Clostridium botulinum (botulism, toxin) … a testing site for anthrax spore bombs used by the British government during WWII (1941). With this attack, the group claimed to be returning the “seeds of death” to their source. …
ncbi.nlm.nih.gov › pmc › articles › PMC4295216
Anthrax: A disease of biowarfare and public health importance
Anthrax toxin consists of PA, LF and EF. Antibodies response against these toxin components is used as a diagnostic tool for determination of past infection or vaccination. It is well established that PA is the most important protein of anthrax tripartite toxin and it becomes the major component of anthrax vaccines including anthrax vaccine …
ncbi.nlm.nih.gov › books › NBK98398
2 Assessing Our Understanding of the Threats – National Center for …
The anthrax toxin, which causes edema and cell necrosis, probably contributes to death as well. … Production and Delivery of Botulinum Toxinas a Bioweapon. … other pathogens intentionally introduced into food and/or water supplies could also negatively affect the ability of a community to respond to the disease. Widespread disease could …
pbs.org › wgbh › americanexperience › features › weapon-timeline
A History of Biological Weapons | American Experience | PBS
This timeline recounts the history of biological weapons, from 1763 to 2003.
ncbi.nlm.nih.gov › books › NBK557387
Botulinum Toxin – StatPearls – NCBI Bookshelf
Botulinum toxin is a medication used to manage and treat therapeutic and cosmetic purposes. Medicinal uses include chronic migraine, spastic disorders, cervical dystonia, and detrusor hyperactivity. Botulinum toxin is in the neurotoxin class of medications. This activity reviews the indications, action, and contraindications for botulinum toxin therapy as a valuable agent for therapeutic and …
emergency.cdc.gov › agent › ricin › clinicians › epidemiology.asp
CDC Ricin | Epidemiological Overview for Clinicians
It takes a deliberate act to make ricin and use it as a poison. Those at risk for ricin poisoning include Persons in the dispersal area of a ricin aerosol release, if ricin is used as an agent of terrorism. Persons who are victims of parenteral injection with ricin. Persons who ingest castor beans, or food or water contaminated with ricin.
ncbi.nlm.nih.gov › pmc › articles › PMC7149987
Seeds of Destruction – PMC – National Center for Biotechnology Information
Pathogens and biological toxins have been used as weapons throughout history. Some would argue that biological warfare began when medieval armies used festering corpses to contaminate water supplies. Over several centuries this evolved into the development of sophisticated biological munitions for battlefield and covert use.
emedicine.medscape.com › article › 829125-overview
CBRNE – Botulism: Practice Essentials, Background, Pathophysiology
It is estimated that one gram of aerosolized botulism toxin has the potential to contain 1.5 lethal doses. Botulinum toxin is classified by the Centers for Disease Control and Prevention (CDC) as one of the six highest-risk threat agents for bioterrorism because of the high lethality, ease of production and transport, and need for prolonged …
pubmed.ncbi.nlm.nih.gov › 28163472
Botulinum toxin the poison that heals: A brief review – PubMed
Botulinum neurotoxins, causative agents of botulism in humans, are produced by Clostridium botulinum, an anaerobic spore-former Gram-positive bacillus.Botulinum neurotoxin poses a major bioweapon threat because of its extreme potency and lethality; its ease of production, transport, and misuse; and the need for prolonged intensive care among affected persons.
ncbi.nlm.nih.gov › books › NBK570614
Comprehensive Review of Bioterrorism – StatPearls – NCBI Bookshelf
Biological weapons are devices or agents used or intended to be used in a deliberate attempt to disseminate disease-producing organisms or toxins using aerosol, food, water, or insect vectors. Their mechanism of action tends to be broadly through infection or intoxication.[1] Bioterrorism involves the deliberate release of bioweapons to cause death or disease in humans, animals, or plants …
en.m.wikipedia.org › wiki › Anthrax_toxin
Anthrax is a disease caused by Bacillus anthracis, a spore-forming, Gram positive, rod-shaped bacterium (Fig. 1).The lethality of the disease is causedby the bacterium’s two principal virulence factors: (i) the polyglutamic acid capsule, which is anti-phagocytic, and (ii) the tripartite protein toxin, called anthrax toxin.Anthrax toxin is a mixture of three protein components: (i) protective …
ncbi.nlm.nih.gov › books › NBK459273
Botulism – StatPearls – NCBI Bookshelf – National Center for …
Botulism is a rare but potentially fatal syndrome of diffuse, flaccid paralysis caused by botulinum neurotoxin (BoNT), an exo neurotoxin elaborated by the bacterium Clostridium botulinum. Since its recognition as a foodborne entity in Germany and Belgium in the 1800s, several other etiologies of botulism have been described, including wound botulism, iatrogenic botulism, and inhalational …
sciencedirect.com › topics › medicine-and-dentistry › …
Biological Warfare – an overview | ScienceDirect Topics
Bio Warfare and Terrorism. M. Balali-Mood, … L. Etemad, in Encyclopedia of Toxicology (Third Edition), 2014 Abstract. Biological warfare is the deliberate use of disease-causing biological agents such as bacteria, virus, rickettsiae, and fungi, or their toxins, to kill or incapacitate humans, animals, or plants as an act of war. The following characteristics of biological warfare make them …
centerforhealthsecurity.org › resources › fact-sheets-by-the…
Fact Sheets | Johns Hopkins Center for Health Security
Botulinum toxins pose a major threat as biological weapons because they are extremely potent and lethal; some of the toxins are relatively easy to produce and transport; and people with botulism require prolonged intensive hospital care. … in recent history—the Jonestown Massacre in 1978 and the Tylenol poisonings in 1982—highlight the …
theatlantic.com › … › 12 › how-not-to-die-of-botulism › 281649
How Not to Die of Botulism – The Atlantic
Highly-poisonous botulinum toxin (the stuff in Botox), played a formidable role in the history of food and warfare. It is still a factor in prison-brewed alcohol and some canned foods, and can …
frontiersin.org › journals › tropical-diseases › articles › 10….
Frontiers | Anthrax outbreak: exploring its biological agents and …
Interestingly, B. anthracis has also been established as a bioweapon, and was used as such for the first time in the United States in an incident in 2001 when anthrax spores were mailed to certain government officials. This was…
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