The local and systemic response to SARS-CoV-2 infection in children and adults. Schematic summary of the difference of the airway and systemic immune response to SARS-CoV-2 infection between children and adults, reflecting the maturation of the immune landscape throughout childhood to adulthood. Key points are: (1) Immune cell proportions display strong maturation patterns throughout healthy child- and adulthood, with a notable innate to adaptive immunity switch. (2) In airways, the local innate IFN response to SARS-CoV-2 is stronger in pediatric airway immune cells compared to adult ones. (3) In blood, the systemic innate IFN response to SARS-CoV-2 is stronger in…
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