How to Prevent Chronic Diseases, Such As Atherosclerosis, Cancers, Diabetes, Heart Diseases,... and Stroke Caused by Oxidative Stress
Kyle J. Norton
Carrots may have a profound and positive effect in reduced oxidative stress in induction of related chronic diseases, including atherosclerosis, cancers, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases,… and stroke, some scientists suggested.
Oxidative stress is the indication of over expression free radicals in the body due to depletion of antioxidants produced by the host tissue.
According to the Department of Biotechnology, M. J. College,”Overproduction of free radicals can cause oxidative damage to biomolecules, (lipids, proteins, DNA), eventually leading to many chronic diseases”.
The studies of carrots in reduced over production of reactive oxygen species in facilitated oxidative stress were carried out by several respectable institutes and the results were published online medical literature.
Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
In the investigation of the relation of dietary supplementation with lycopene (LYC), a major active biochemical compound found in carrot, on age-induced cognitive impairment, and the potential underlying mechanisms, using the behavioral tests, researchers at Northwest A&F University, researchers found that chronic injection of LYC exerts a potential effect in alleviated age-associated memory loss and cognitive defects through several mechanisms
Application of lycopene improved antioxidant produced by the host body in countering to the over expression of free radicals, including glutathione, catalase, and superoxide dismutase activities and the levels of antioxidant-enzyme.
Treatment of the phytochemical displayed a strong activity in reversed age-associated neuronal damage and synaptic dysfunctions in the brain, through inhibited the levels of malondialdehyde (MDA) levels in associated to oxidative stress.
Malondialdehyde (MDA) levels is considered as oxidative maker used in treatment of cancers and other oxidative related diseases.
Interestingly, researchers also indicated that chronic injection of bioactive lycopene lower the levels of the accumulation of Aβ1-42 in the brains in aged CD-1 mice model.
Evidences findings suggested that Aβ-induced oxidative stress may place the majority of the causative effect of increased cellular oxidative stress upon oligomeric Aβ(1–42).
Further more, LYC supplementation also significantly reduced age-associated neuroinflammation caused by over expression of free radicals in activation of proinflammatory cytokines by inhibiting microgliosis (Iba-1) in response to damage to the central nervous system (CNS) and related inflammatory chemicals mediators.
These results overwhelmingly suggested that lycopene injection processes a strong effect in reduced risk and treatment of diseases associated to over production of ROS, through re-balancing the ratio of antioxidant and free redials in the host body.
Moreover, in d-galactose induced CD-1 male mice cognitive impairments, chronic LYC supplementation (50 mg/kg bodyweight per day) demonstrated a significant activity in inhibition of oxidative stress-induced cognitive defects.
Injection of lycopene also ameliorated histopathological damage and restored brain derived neurotrophic factor (BDNF) levels in the hippocampus of mice. This findings reaffirms the conclusion of the Northwest A&F University study.
LYC treatment in animal model, also increased antioxidant of the host by activating the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and inhibited the oxidative stress in induction of inflammatory cytokines IL-1β and TNF-α in host hippocampus.
More precisely, LYC attenuated neuronal oxidative damage through activation of Nrf2 signaling in increased levels of anti inflammatory mytokines and inactivation of NF-κB translocation in signalling pro inflammatory expression.
Dr. Zhao B, the lead scientist, after taking into account of co and confounders said, ” LYC could ameliorate oxidative stress induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway”.
The findings indicated that carrot with major active compound lycopene may be considered as function foods in prevention and treatment of oxidative related diseases by restoring the ratio of reactive oxygen species and levels of antioxidant in the body.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice by Zhao B1, Liu H1, Wang J1, Liu P1, Tan X1, Ren B1, Liu Z1, Liu X(PubMed)
(2) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X2(PubMed)