Melatonin and circadian rhythms and sleep
Home of Kyle J. Norton for The Better of Living & Living Health Melatonin, also known as N-acetyl-5-methoxytryptamine, a hormone secreted by the pineal gland in the brain with functions of regulating sleep cycles, other hormones, timing in secretion of female hormones that affect the menstrual cycle, etc. The levels of the circulating hormone vary in a daily cycle, depending to the circadian rhythm is an internal 24-hour “clock”.
Melatonin and circadian rhythms and sleep
melatonin is an internal sleep “facilitator” in humans, and therefore useful in the treatment of insomnia and the readjustment of circadian rhythms. In the study of Role of melatonin in the regulation of human circadian rhythms and sleep, researchers found that administration of melatonin is able: (i) to induce sleep when the homeostatic drive to sleep is insufficient; (ii) to inhibit the drive for wakefulness emanating from the circadian pacemaker; and (iii) induce phase shifts in the circadian clock such that the circadian phase of increased sleep propensity occurs at a new, desired time(11).
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(11) http://www.ncbi.nlm.nih.gov/pubmed/12622846
http://medicaladvisorjournals.blogspot.com
2012-11-24 17:40:20
Source: http://medicaladvisorjournals.blogspot.com/2012/11/melatonin-and-circadian-rhythms-and.html
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Melatonin’s ability “to inhibit the drive for wakefulness” probably related to its disruptive effect on the metabolism, leaving numerous people feeling groggy and tired during the day. Beyond that, melatonin was found to be implicated in the release of some stress hormones, hypertension, the generation of inflammation, a higher mortality, etc (see http://www.supplements-and-health.com/tryptophan-side-effects.html ). Caution may be in place if considering to raise it with supplements longterm.