Brush Your Teeth and Postpone Alzheimer´s
You don’t only avoid holes in your teeth by keeping good oral hygiene, researchers at the University of Bergen have discovered a clear connection between gum disease and Alzheimer´s disease.
The researchers have determined that gum disease (gingivitis) plays a decisive role in whether a person develops Alzheimer´s or not.
“We discovered DNA-based proof that the bacteria causing gingivitis can move from the mouth to the brain,” says researcher Piotr Mydel at Broegelmanns Research Laboratory, Department of Clinical Science, University of Bergen (UiB).
The bacteria produces a protein that destroys nerve cells in the brain, which in turn leads to loss of memory and ultimately, Alzheimer´s.
The study is published in Science Advances.
Brush your teeth for better memory
Mydel points out that the bacteria is not causing Alzheimer´s alone, but the presence of these bacteria raise the risk for developing the disease substantially and are also implicated in a more rapid progression of the disease. However, the good news is that this study shows that there are some things you can do yourself to slow down Alzheimer´s.
“Brush your teeth and use floss”.
Mydel adds that it is important, if you have established gingivitis and have Alzheimer´s in your family, to go to your dentist regularly and clean your teeth properly.
New medicine being developed
Researchers have previously discovered that the bacteria causing gingivitis can move from the mouth to the brain where theharmful enzymes they excrete can destroy the nerve cells in the brain.
Now, for the first time, Mydel has DNA-evidence for this process from human brains. Mydel and his colleagues examined 53 persons with Alzheimer´s and discovered the enzyme in 96 per cent of the cases. According to Mydel, this knowledge gives researchers a possible new approach for attacking Alzheimer´s disease.
“We have managed to develop a drug that blocks the harmful enzymes from the bacteria, postponing the development of Alzheimer´s. We are planning to test this drug later this year, says Piotr Mydel.
Contacts and sources:
Kim E. Andreasssen
The University of Bergen
Citation: Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Stephen S. Dominy, Casey Lynch, Florian Ermini, Malgorzata Benedyk, Agata Marczyk, Andrei Konradi, Mai Nguyen, Ursula Haditsch, Debasish Raha, Christina Griffin, Leslie J. Holsinger, Shirin Arastu-Kapur, Samer Kaba, Alexander Lee, Mark I. Ryder, Barbara Potempa, Piotr Mydel, Annelie Hellvard, Karina Adamowicz, Hatice Hasturk, Glenn D. Walker, Eric C. Reynolds, Richard L. M. Faull, Maurice A. Curtis, Mike Dragunow, Jan Potempa. Science Advances, 2019; 5 (1): eaau3333 DOI: 10.1126/sciadv.aau3333
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Whistler Blowers, Insiders
My gums improved when mornings I started taking 500 mg of the bioflavonoid, hesperidin.
BulkSupplements has hesperidin in powder so I order it in the 250 gram or 500 gram bag. Mornings I take 1/2 level measuring teaspoon (about 1 gram) with water. If my gums are having any problem, I take an afternoon dose as well.
SwansonVitamins and PipingRock have hesperidin in 500 mg capsules, but the bulk powder has less fillers.
My occasionally bleeding gums and slightly loose teeth started improving in a few days and continued to improve over the next 2 years.
So that is a neat thing if hesperidin would prevent Alzheimer’s by keeping gums healthy, or possibly would reverse Alzheimer’s. Sounds like it is worth a try to me, to give all Alzheimer’s patients 1 gram of hesperidin say twice per day.
As for teeth, I found that the NOW brand Calcium Hydroxyapatite (CH) Caps heal sensitive teeth and prevent cavities. SwansonVitamins and PipingRock carry it in a bottle of 120 capsules, as well as other online stores.
I take 1 to 4 capsules per day, depending on conditions such as whether I may have injured a tooth that needs be given a chance to heal itself. I had a flax seed put a small hole in a molar and the CH healed it over days or weeks.