Read the Beforeitsnews.com story here. Advertise at Before It's News here.
Profile image
By Alton Parrish (Reporter)
Contributor profile | More stories
Story Views
Now:
Last hour:
Last 24 hours:
Total:

Cannabigerol (CBG): Researchers Uncover Hidden Antibiotic Potential of Cannabis

% of readers think this story is Fact. Add your two cents.


McMaster University researchers have identified an antibacterial compound made by cannabis plants that may serve as a lead for new drug development.

An interdisciplinary team of McMaster researchers found that the chemical compound, or cannabinoid, called cannabigerol (CBG) is not only antibacterial but also effective in mice against a resilient family of bacteria known as methicillin-resistant Staphylococcus aureus (MRSA).

Photo caption: Professor Eric Brown (left); research associate Maya Farha (centre), and postdoctoral fellow Omar El-Halfawy, are authors of the study and members of the Michael G. DeGroote Institute for Infectious Disease Research and Department of Biochemistry and Biomedical Sciences at McMaster University. 
Photo courtesy McMaster University

The findings were published in the journal American Chemical Society Infectious Diseases.

“In this study, we investigated 18 commercially available cannabinoids and they all showed antibiotic activity, some much more than others,” said study lead Eric Brown, professor of biochemistry and biomedical sciences at McMaster.

“The one we focused on was a non-psychoactive cannabinoid called CBG, as it had the most promising activity. We synthesized that cannabinoid in mass quantity which gave us sufficient compound to go deep into the research.”

The research team found that CBG had antibacterial activity against drug-resistant MRSA. It prevented the ability of that bacteria to form biofilms, which are communities of microorganisms that attach to each other and to surfaces; and it destroyed preformed biofilms and cells resistant to antibiotics. CBG achieved this by targeting the cell membrane of the bacteria.

These findings in the laboratory were supported when mice with an MRSA infection were given CBG.

“CBG proved to be marvellous at tackling pathogenic bacteria,” Brown said. “The findings suggest real therapeutic potential for cannabinoids as antibiotics.”

One caveat noted by the research team is the toxicity of CBG on the host cells which makes the study’s findings an important lead rather than a likely final product, Brown said.

“It opens a therapeutic window, but a narrow one, to develop this into a drug,” he said. “The next steps are to try to make the compound better in that it is more specific to the bacteria and has a lower chance of toxicity.”

The Brown lab has been studying the antibiotic potential of cannabis for the past two years since the legalization of marijuana in Canada.

“This research became top of mind for us, in part, because we are in Canada,” Brown said. “There has been some stigma of investing in this kind of research, but there’s increasing anecdotal evidence of the medicinal use of cannabis. The stigma seems to be waning.”

Brown said the study was reliant on his collaborator, Jakob Magolan, a McMaster associate professor of biochemistry and biomedical sciences who specializes in drug development using organic synthetic chemistry.

“The labs of Jake and I are just steps away from each other and our teams are talking to each other all the time,” Brown said. “This is just one of many exciting projects we’re involved with that combine scientists with very different but complementary expertise.”

The study was funded by McMaster’s Michael G. DeGroote Centre for Medicinal Cannabis Research, Faculty of Health Sciences and Michael G. DeGroote Institute for Infectious Disease Research.

Contacts and sources:
Veronica McGuire
McMaster University

 


Source:


Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world.

Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.

"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.

Lion’s Mane Mushroom

Mushrooms are having a moment. One fabulous fungus in particular, lion’s mane, may help improve memory, depression and anxiety symptoms. They are also an excellent source of nutrients that show promise as a therapy for dementia, and other neurodegenerative diseases. If you’re living with anxiety or depression, you may be curious about all the therapy options out there — including the natural ones.Our Lion’s Mane WHOLE MIND Nootropic Blend has been formulated to utilize the potency of Lion’s mane but also include the benefits of four other Highly Beneficial Mushrooms. Synergistically, they work together to Build your health through improving cognitive function and immunity regardless of your age. Our Nootropic not only improves your Cognitive Function and Activates your Immune System, But it benefits growth of Essential Gut Flora, further enhancing your Vitality.



Our Formula includes:

Lion’s Mane Mushrooms which Increase Brain Power through nerve growth, lessen anxiety, reduce depression, and improve concentration. Its an excellent adaptogen, promotes sleep and improves immunity.

Shiitake Mushrooms which Fight cancer cells and infectious disease, boost the immune system, promotes brain function, and serves as a source of B vitamins.

Maitake Mushrooms which regulate blood sugar levels of diabetics, reduce hypertension and boosts the immune system.

Reishi Mushrooms which Fight inflammation, liver disease, fatigue, tumor growth and cancer. They Improve skin disorders and soothes digestive problems, stomach ulcers and leaky gut syndrome.

Chaga Mushrooms which have anti-aging effects, boost immune function, improve stamina and athletic performance, even act as a natural aphrodisiac, fighting diabetes and improving liver function.

Try Our Lion’s Mane WHOLE MIND Nootropic Blend 60 Capsules. Today Be 100% Satisfied Or Receive A Full Money Back Guarantee Order Yours Today By Following This Link.

Report abuse

    Comments

    Your Comments
    Question   Razz  Sad   Evil  Exclaim  Smile  Redface  Biggrin  Surprised  Eek   Confused   Cool  LOL   Mad   Twisted  Rolleyes   Wink  Idea  Arrow  Neutral  Cry   Mr. Green

    MOST RECENT
    Load more ...

    SignUp

    Login

    Newsletter

    Email this story
    Email this story

    If you really want to ban this commenter, please write down the reason:

    If you really want to disable all recommended stories, click on OK button. After that, you will be redirect to your options page.