Artificial Molecule Can Imitate and Outcompete DNA
Researchers at the Institut de chimie et biologie des membranes et nano-objets (CNRS/Bordeaux University/Bordeaux INP),1 the Laboratoire de microbiologie fondamentale et pathogénicité (CNRS/Bordeaux University) and the Institut de recherche en cancérologie de Montpellier (Inserm/Montpellier University) have successfully synthesized helical molecules that precisely imitate the surface features of DNA’s double helix and notably the position of its negative charges.
These DNA mimics pave the way for as yet unexplored approaches to inhibiting DNA–protein interactions, which could, in the future, lead to new medicines.
1 Including researchers from Ivan Huc’s team at the Institut européen de chimie et biologie (CNRS/Inserm/Bordeaux University).
Contacts and sources:
CNRS (Délégation Paris Michel-Ange)
Citation: Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA. Krzysztof Ziach, Céline Chollet, Vincent Parissi, Panchami Prabhakaran, Mathieu Marchivie, Valentina Corvaglia, Partha Pratim Bose, Katta Laxmi-Reddy, Frédéric Godde, Jean-Marie Schmitter, Stéphane Chaignepain, Philippe Pourquier, and Ivan Huc. Nature Chemistry, April 2, 2018. https://www.nature.com/articles/s41557-018-0018-7
Source: https://www.ineffableisland.com/2018/04/artificial-molecule-can-imitate-and.html
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