Anti-vaccinationists have been promoting an
abstract of a poster to be presented at the forthcoming American Heart Association meeting as A) a peer-reviewed publication (it’s not, conference poster abstracts are not peer-reviewed in any meaningful sense, and it is flagged with
an expression of concern) and B) demonstrating significant heart inflammation which increases cardiac risk. The abstract states:
We conclude that the mRNA vacs dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination.
Except well.. it doesn’t.
I graphed the data from the abstract, it doesn’t support the claims, basically, the inflammatory markers are not elevated. Look at the error bars, they are very wide and overlap substantially between pre- and post- vax measures, which means there is no meaningful difference between the figures, indeed for IL-16 there is a possibility that the real postvax value is actually lower than prevax).
The PULS test (Protein Unstable Lesion Signature Test, misstyped as PLUS in the abstract, the author couldn’t even get the name of the test he used right), measures a panel of 9 proteins associated with atherosclerotic plaques, including proteins related to inflammation, apoptosis, thrombosis and vascular remodeling (IL-16, sFas, Fas ligand, HGF, HDL, Eotaxin, MCP-3,CTACK and HbA1c, don’t worry about what all the abbreviations mean) as well as things like blood pressure and cholesterol levels to predict the likelihood of a cardiac event (from rupture of a blood vessel in the heart, to clotting etc).
I could find no independent validation of this test (one site that sells this test claimed 61% predictive utility
for any cardiac event, not that good even for the intended use. A
similar test, the CHDRA algorithm, has been tested and is somewhat better than the
Framingham risk score in predicting 5 year risk of cardiac events but again incorporates a lot more data than just the panel of 9 proteins (and is still only moderately better than tossing a coin).
Importantly the
CHDRA algorithm is meant to weigh l
ong term risk factors against the risk of cardiac events,
not transient changes associated with infection or vaccination.
However, note that only
3 of the 9 proteins in the CHDRA panel are reported, not enough to calculate a coronary risk score. Furthermore there is no actual data shown (eg. IL-16 is normally reported in ng/Litre or
pg/mL), just an arbitrary “elevation above the norm”. There is no indication how the “normal” baseline is determined (what is population the “norm was based on? how many subjects, what was their health status? what age and sex distribution?). Are they using an average value or the upper limit of the reference range (however derived)?
There is no indication of inter-test variability (ie how variable is the data from a the same subject taken three months apart, is the variation shown just the normal variability of the populations?). Normal changes over time not controlled for, there is no group of similarly aged people who have not been vaccinated tested over the same time interval.
Then again, it’s not like finding inflammatory markers 2-10 days after a vaccination which induces inflammation is a surprise.
We already knew that.
If you look at the panel to the left you can see that IL-16 is elevated on days 2 and 8 after vaccination and returns to baseline by day 22. That the PULS test results in the abstract can’t even show this clearly shows how rubbish the study is.
The data not only fail to show a consistent increase in the 3 of 9 biomarkers they picked, they also show no evidence of endothelial inflammation (
IL-16 is produced by many cells, including lymphocytes that would be expected to be activated by vaccines (or infection) let along T-cell infiltration of cardiac muscle (that’s basically made up).
Take home message: While we might expect to see some inflammation after vaccination, this abstract can’t even show that, let alone show it has anything to do with the heart. In short, it is nonsense.
Source:
http://astroblogger.blogspot.com/2021/11/no-mrna-vaccines-do-not-increase-your.html
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