Lab-Grown Brain Organoids Age Like Real Brains and Record Development
Scientists have kept human brain organoids alive and maturing in the laboratory for more than five years, some even reaching seven years, setting a new longevity record and showing that these tiny clusters of cells track the passage of time much like a developing human brain. The breakthrough, published in Nature on 19 August 2026, comes from a team led by Paola Arlotta at Harvard University and the Broad Institute. It opens new windows onto later stages of brain development that were previously inaccessible in the lab.
Brain organoids are three-dimensional models grown from human pluripotent stem cells. Roughly the size of a peppercorn, they contain more than a million cells and spontaneously organize into structures resembling the cerebral cortex. Until now most organoids survived only a few months and largely mirrored early prenatal stages. By optimizing culture conditions with an activity-permissive medium, the researchers extended the life of excitatory neurons far beyond previous limits.
Over years in culture the organoids continued to change. Single-cell RNA sequencing of more than 424,000 cells from 110 organoids revealed cell-type-specific maturation that paralleled human brain development: early organoids matched first-trimester gene expression, later ones shifted toward second-trimester and then postnatal patterns. After one year they showed signatures similar to a newborn brain; by five years they resembled aspects of a young child’s cortex.
www.Ancient-Origins.net – Reconstructing the story of humanity’s past
Source: https://www.ancient-origins.net/news-science-space/brain-organoids-00103119
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